Drug interactions between amlodipine and Carbatrol
| Results for the following 2 drugs: |
|---|
| amlodipine |
| Carbatrol (carbamazepine) |
Interactions between your selected drugs
carbamazepine ↔ amlodipine
Applies to:Carbatrol (carbamazepine) and amlodipine
MONITOR: Some calcium channel blockers may reduce the CYP450 3A4 hepatic metabolism of carbamazepine. Carbamazepine serum levels and risk of toxicity may increase. In addition, carbamazepine may reduce the bioavailability of some calcium channel blockers by induction of CYP450 3A4 metabolism. Serum levels and activity of calcium channel blockers may be decreased. Data are available for verapamil, felodipine, and diltiazem.
MANAGEMENT: If alternative therapy is not appropriate, close observation is recommended for altered efficacy and safety of both drugs whenever either is added, discontinued, or changed in dosage. Patients should be advised to report worsening of their symptoms and signs of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia) to their caregiver. Dose adjustments may be required.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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