Drug interactions between amiodarone and loratadine
Results for the following 2 drugs: |
|
|---|---|
| amiodarone | |
| loratadine | |
Interactions between your selected drugs
amiodarone ⇔ loratadine
Applies to: amiodarone and loratadine
MONITOR: QT interval prolongation and torsade de pointes have been reported with the coadministration of loratadine and amiodarone. A 73-year-old woman receiving chronic therapy with amiodarone developed syncope and multiple episodes of torsade de pointes following the addition of loratadine. The exact mechanism of interaction is unknown. Although QT interval prolongation and torsade de pointes are known adverse effects of amiodarone, they have not been associated with loratadine. It is possible that loratadine competitively inhibits the metabolism of amiodarone via CYP450 3A4, since both are substrates of the isoenzyme.
MANAGEMENT: Until more information is available, it may be appropriate to monitor QT interval whenever loratadine is coadministered with amiodarone. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, palpitations, or syncope.
See also...
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2009 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
