Drug interactions between Amerge and caffeine/ergotamine
| Results for the following 2 drugs: |
|---|
| Amerge (naratriptan) |
| caffeine/ergotamine |
Interactions between your selected drugs
ergotamine ↔ naratriptan
Applies to:caffeine/ergotamine and Amerge (naratriptan)
CONTRAINDICATED: Coadministration of two or more 5-HT1 receptor agonists and/or ergotamine-containing or ergot-type medications may potentiate the risk of vasospastic reactions, including coronary artery vasospasm, peripheral vascular ischemia and colonic ischemia, due to additive pharmacologic effects. Acute myocardial infarction due to sustained vasospasm occurred in a premenopausal woman with controlled hypertension and no known history of coronary artery disease following two 2 mg doses of methysergide maleate 12 hours apart and a subcutaneous injection of sumatriptan 6 mg.
MANAGEMENT: The concomitant use of two or more 5-HT1 receptor agonists and/or ergotamine-containing or ergot-type medications, or use within 24 hours of each other, is considered contraindicated.
See also...
- Caffeine/ergotamine Drug Interactions
- caffeine and ergotamine oral/rectal General Consumer Information
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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