Drug Interactions

Drug interactions between Ambien and Cardizem

Results for the following 2 drugs:

Ambien (zolpidem)
Cardizem (diltiazem)

Interactions between your selected drugs

diltiazem ⇔ zolpidem

Applies to: Cardizem (diltiazem) and Ambien (zolpidem)

Use of drugs that inhibit the isoenzyme CYP450 3A4 may decrease the metabolism and increase the plasma levels of zolpidem. This can result in increased clinical effectiveness and risk of toxicity associated with zolpidem. Monitoring for signs and symptoms of altered zolpidem effect is recommended. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, confusion, daytime sedation, dizziness, or unconsciousness. A reduction in zolpidem dosage may be necessary.

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