Drug interactions between alprazolam and Biaxin
Results for the following 2 drugs: |
|
|---|---|
| alprazolam | |
| Biaxin (clarithromycin) | |
Interactions between your selected drugs
clarithromycin ⇔ alprazolam
Applies to: Biaxin (clarithromycin) and alprazolam
MONITOR: Macrolide antibiotics may increase and prolong the CNS effects of certain benzodiazepines. The mechanism is inhibition of CYP450 3A4 hepatic oxidation of the benzodiazepines. Midazolam, triazolam, and alprazolam have been specifically studied in this regard. Lorazepam, oxazepam, and temazepam are hepatically conjugated and are not expected to interact. Azithromycin and dirithromycin do not inhibit CYP450 isoenzymes.
MANAGEMENT: Patients receiving this combination should be monitored for excessive or prolonged sedation. Non-interacting benzodiazepines or antimicrobials may be considered as alternatives.
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