Drug interactions between Allegra and Rifadin
Results for the following 2 drugs: |
|
|---|---|
| Allegra (fexofenadine) | |
| Rifadin (rifampin) | |
Interactions between your selected drugs
rifampin ⇔ fexofenadine
Applies to: Rifadin (rifampin) and Allegra (fexofenadine)
MONITOR: The coadministration with rifampin may decrease the oral bioavailability of fexofenadine. The mechanism is rifampin induction of intestinal P-glycoprotein, resulting in increased secretion and decreased absorption of fexofenadine. In 24 healthy volunteers divided into 4 groups by age and gender, rifampin (600 mg orally once a day for 6 days) increased the oral clearance of fexofenadine (60 mg single oral dose) in the different groups by 87% to 169% compared to when fexofenadine was administered alone. Mean peak plasma concentration (Cmax) decreased by 32% to 51%, while terminal half-life and renal clearance were not affected. The effect of rifampin on fexofenadine pharmacokinetics was independent of age and sex. MANAGEMENT: Patients treated with rifampin should be monitored for potentially diminished or inadequate therapeutic response to fexofenadine.
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