alinia and Valrelease Interactions

Interactions between alinia(nitazoxanide) and Valrelease (diazepam)

diazepam and nitazoxanide (Minor Drug-Drug)

Nitazoxanide may increase the potential for toxicity of other highly plasma protein bound drugs. The mechanism of action is competition for plasma protein binding sites. Tizoxanide, its active metabolite, is over 99.9% plasma protein bound. The clinical significance is unknown. Caution is recommended when highly protein bound drugs with narrow therapeutic indices are administered concurrently. Additionally, total plasma concentrations should be interpreted cautiously, because a greater amount of free drug may be present.