Drug interactions between Afeditab CR and Ginkgo Biloba
| Results for the following 2 drugs: |
|---|
| Afeditab CR (nifedipine) |
| Ginkgo Biloba (ginkgo) |
Interactions between your selected drugs
nifedipine ↔ ginkgo
Applies to:Afeditab CR (nifedipine) and Ginkgo Biloba (ginkgo)
MONITOR: Coadministration with ginkgo or ginseng has been found to increase the plasma concentrations of nifedipine in one study. The mechanism of interaction is unknown. Nifedipine is a known substrate of CYP450 3A4; however, the effects of ginkgo or ginseng on CYP450 3A4 metabolism have not been established. Limited in vitro data suggest that certain formulations such as ginkgo leaf extract or Siberian ginseng whole plant or root extracts may possess some CYP450 3A4-inhibiting activity. In the nifedipine study, pretreatment with ginkgo biloba (120 mg/day) and ginseng (200 mg/day) for 18 days increased the mean plasma concentration (at 0.5 hour postdose) of a single 10 mg dose of nifedipine by 53% and 29%, respectively, compared to administration of nifedipine alone in 22 healthy volunteers. The specific formulations of ginkgo and ginseng used were not specified.
MANAGEMENT: Patients should consult a healthcare provider before taking any herbal or alternative medicine. Nifedipine dosage may require adjustment if an interaction is suspected.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2012 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
