Drug interactions between Aerobid and mifepristone
| Results for the following 2 drugs: |
|---|
| Aerobid (flunisolide) |
| mifepristone |
Interactions between your selected drugs
flunisolide ↔ mifepristone
Applies to:Aerobid (flunisolide) and mifepristone
CONTRAINDICATED: Mifepristone is a potent antiglucocorticoid and may antagonize the effects of corticosteroids. In animals, mifepristone at dosages of 10 to 25 mg/kg inhibited the action of dexamethasone. In human, the antiglucocorticoid action occurred at dosages of 4.5 mg/kg or greater, as indicated by a compensatory elevation of adrenocorticotropic hormone (ACTH) and cortisol. The efficacy of chronic corticosteroid therapy, including inhaled corticosteroids, may be reduced for 3 to 4 days after a single dose of mifepristone. Pharmacokinetically, mifepristone may increase the plasma concentrations of corticosteroids by inhibiting their metabolism via CYP450 3A4. However, the clinical impact has not been studied. Dexamethasone, specifically, may also decrease the blood levels of mifepristone by inducing its metabolism via CYP450 3A4.
MANAGEMENT: The use of mifepristone is considered contraindicated in patients on long-term corticosteroid therapy. When intended for daily use to control hyperglycemia secondary to hypercortisolism in patients with endogenous Cushing's syndrome, mifepristone is also contraindicated in those patients who require systemic corticosteroids for serious medical conditions or illnesses, such as immunosuppression after organ transplantation. Because mifepristone is eliminated slowly from the body, drug interactions may be observed for a prolonged period following discontinuation (approximately 2 to 3 weeks if mifepristone had been administered chronically to steady state).
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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