Drug interactions between Advicor and Coumadin
| Results for the following 2 drugs: |
|---|
| Advicor (lovastatin/niacin) |
| Coumadin (warfarin) |
Interactions between your selected drugs
warfarin ↔ lovastatin
Applies to:Coumadin (warfarin) and Advicor (lovastatin/niacin)
MONITOR: Lovastatin may enhance the hypoprothrombinemic effects of warfarin. Clinically significant alterations in anticoagulation have been reported. The mechanism is unknown.
MANAGEMENT: Caution is recommended if any HMG-CoA reductase inhibitor is used concomitantly with any oral anticoagulant. Close clinical and laboratory monitoring for altered anticoagulant effect is recommended. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools. Preliminary studies have shown that pravastatin and cerivastatin do not affect the anticoagulant response to warfarin.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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