Drug interactions between Adapin and Tagamet
| Results for the following 2 drugs: |
|---|
| Adapin (doxepin) |
| Tagamet (cimetidine) |
Interactions between your selected drugs
cimetidine ↔ doxepin
Applies to:Tagamet (cimetidine) and Adapin (doxepin)
MONITOR: Cimetidine may increase the serum concentration of tricyclic antidepressants (TCAs) to toxic levels in some patients. The mechanism may be related to inhibition of CYP450 hepatic metabolism of TCAs.
MANAGEMENT: Close monitoring for clinical response and tolerance is recommended whenever cimetidine is added to or discontinued from a TCA regimen. Patients should be advised to notify their physician if they experience excessive TCA effects such as dry mouth, blurry vision, irregular or fast heartbeat, constipation, urinary retention, dizziness, or orthostatic hypotension. Lower doses of tricyclic antidepressants may be necessary. Ranitidine, famotidine, and nizatidine are not expected to interact and may be an alternative to cimetidine in this circumstance.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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