Drug interactions between Adapin and Romazicon
| Results for the following 2 drugs: |
|---|
| Adapin (doxepin) |
| Romazicon (flumazenil) |
Interactions between your selected drugs
doxepin ↔ flumazenil
Applies to:Adapin (doxepin) and Romazicon (flumazenil)
GENERALLY AVOID: Severe adverse effects, including fatalities, have been reported following the administration of flumazenil to multiple-drug-overdose patients who have taken large quantities of tricyclic antidepressants. The effects have included seizures and arrhythmias (including ventricular tachycardia). The mechanism of this interaction may be related to a decrease in the protective antiseizure effects of benzodiazepines that patients may have taken concomitantly with overdoses of tricyclic antidepressants.
MANAGEMENT: Administration of flumazenil should be avoided in patients who are known or suspected to have received overdoses of tricyclic antidepressants.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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