Drug interactions between Adapin and ramelteon
| Results for the following 2 drugs: |
|---|
| Adapin (doxepin) |
| ramelteon |
Interactions between your selected drugs
doxepin ↔ ramelteon
Applies to:Adapin (doxepin) and ramelteon
MONITOR: The concomitant use of doxepin and ramelteon may increase the systemic exposure to ramelteon. The mechanism has not been reported. After administration of doxepin 10 mg/day for 23 days and a single 8 mg dose of ramelteon, the overall exposure (AUC) to ramelteon increased by approximately 66% and the Cmax increased by 69%.
MANAGEMENT: Close monitoring of patients is recommended during coadministration.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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