Drug interactions between Adapin and Pondimin
| Results for the following 2 drugs: |
|---|
| Adapin (doxepin) |
| Pondimin (fenfluramine) |
Interactions between your selected drugs
doxepin ↔ fenfluramine
Applies to:Adapin (doxepin) and Pondimin (fenfluramine)
GENERALLY AVOID: The coadministration of fenfluramine and tricyclic antidepressants (TCAs) may result in elevated plasma concentrations of the latter. The mechanism is decreased clearance of TCAs due to inhibition of CYP450 enzymatic activities by fenfluramine. In addition, the combination of fenfluramine with a TCA may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5HT1A receptors.
MANAGEMENT: In general, the concomitant use of multiple serotonergic agents should be avoided if possible, or otherwise approached with caution if potential benefit is deemed to outweigh the risk. Close monitoring is recommended for signs and symptoms of TCA toxicity as well as excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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