Drug interactions between Adapin and Phenytoin Sodium, Prompt
| Results for the following 2 drugs: |
|---|
| Adapin (doxepin) |
| Phenytoin Sodium, Prompt (phenytoin) |
Interactions between your selected drugs
phenytoin ↔ doxepin
Applies to:Phenytoin Sodium, Prompt (phenytoin) and Adapin (doxepin)
MONITOR: Tricyclic antidepressants may increase serum phenytoin levels through an unknown mechanism. Imipramine may affect phenytoin levels more than do other tricyclic antidepressants. Phenytoin may induce the hepatic metabolism of desipramine resulting in decreased effectiveness. In addition, tricyclic antidepressants may lower the seizure threshold.
MANAGEMENT: Clinical monitoring of patient response, tolerance, and serum phenytoin concentrations is recommended. Patients should be advised to notify their physician if they experience loss of seizure control or symptoms of phenytoin toxicity (drowsiness, visual disturbances, change in mental status, nausea, or ataxia). Alternative antidepressants should be considered.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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