Drug interactions between Adapin and Calan
Results for the following 2 drugs: |
|
|---|---|
| Adapin (doxepin) | |
| Calan (verapamil) | |
Interactions between your selected drugs
verapamil ⇔ doxepin
Applies to: Calan (verapamil) and Adapin (doxepin)
MONITOR: Concurrent administration of verapamil may increase tricyclic antidepressant (TCA) serum concentrations. The mechanism appears to be inhibition of CYP450 metabolism. Pharmacologic and toxic effects of TCAs may be increased.
MANAGEMENT: Close monitoring for clinical response and tolerance is recommended whenever verapamil is added to or discontinued from an antidepressant regimen. Patients should be advised to notify their physician if they experience excessive antidepressant effects such as dry mouth, blurry vision, irregular or fast heartbeat, constipation, urinary retention, dizziness, or orthostatic hypotension. Dose adjustments may be necessary.
See also...
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2009 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
