Drug interactions between Adapin and anhydrous calcium iodide/isoproterenol
| Results for the following 2 drugs: |
|---|
| Adapin (doxepin) |
| anhydrous calcium iodide/isoproterenol |
Interactions between your selected drugs
doxepin ↔ isoproterenol
Applies to:Adapin (doxepin) and anhydrous calcium iodide/isoproterenol
MONITOR: The concomitant use of isoproterenol and tricyclic antidepressants may increase the risk of arrhythmias, especially at high doses. The mechanism is not clear. Tachycardia has been reported in clinical studies. Rare cases of malignant cardiac arrhythmias have also been reported in patients who took oral isoproterenol and tricyclic antidepressants; however causality was not clearly established due to excessive doses ingested and the presence of other drugs.
MANAGEMENT: Patients receiving this combination should be monitored and advised to notify their physician if they experience a fast or irregular pulse.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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