Drug interactions between Adapin and altretamine
| Results for the following 2 drugs: |
|---|
| Adapin (doxepin) |
| altretamine |
Interactions between your selected drugs
doxepin ↔ altretamine
Applies to:Adapin (doxepin) and altretamine
MONITOR CLOSELY: The coadministration of altretamine with a monoamine oxidase inhibitor (MAOI) or tricyclic antidepressant may result in severe orthostatic hypotension. The mechanism of interaction has not been established. According to one case report, four patients over 60 years of age experienced symptomatic hypotension after 4 to 7 days of concomitant therapy with altretamine and one of the following: amitriptyline, imipramine, or phenelzine. All patients became asymptomatic within 24 to 96 hours after discontinuing the antidepressant. One patient subsequently received and tolerated nortriptyline without clinical symptoms, although a postural drop in systolic blood pressure was observed.
MANAGEMENT: Caution is advised if altretamine must be used with a MAOI or tricyclic antidepressant, particularly in elderly patients. All patients receiving the combination should be advised to avoid rising abruptly from a sitting or lying position and to contact their physician if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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