acyclovir and Lithonate Interactions

Interactions between acyclovir and Lithonate (lithium)

acyclovir and lithium (Moderate Drug-Drug)

MONITOR: Acyclovir may significantly increase the serum levels of lithium. A case of lithium toxicity was reported in a patient stabilized on lithium for several years who was treated with intravenous acyclovir 10 mg/kg for 6 days for herpes zoster. Serum lithium levels increased fourfold. Acyclovir may competitively inhibit the glomerular filtration of lithium, and this interaction may be dependent on the dose of acyclovir.

MANAGEMENT: Frequent monitoring of lithium levels and close observation for signs of lithium toxicity are recommended during acyclovir therapy. Patients should be advised to notify their physician if they experience symptoms of possible lithium toxicity such as drowsiness, dizziness, weakness, ataxia, vomiting, diarrhea, thirst, blurry vision, tinnitus, tremor, or increased urination.