actron and Methotrexate sodium preservative free Interactions

Interactions between actron(ketoprofen) and Methotrexate sodium preservative free (methotrexate)

ketoprofen and methotrexate (Major Drug-Drug)

MONITOR CLOSELY: Nonsteroidal anti-inflammatory agents (NSAIDs) may interfere with the renal elimination of methotrexate. Pharmacologic effect and toxicity of methotrexate may be increased. Patients who are receiving high doses of methotrexate or who have renal impairment are at greater risk of developing toxicity. Fatalities have been reported. Weekly low-dose methotrexate has been used in combination with NSAIDs to treat rheumatic inflammatory diseases.

MANAGEMENT: Caution should be exercised with concomitant use of these agents, and the patient should be monitored closely for signs and symptoms of bone marrow suppression and nephrotoxicity. Patients should be advised to report possible symptoms of toxicity including nausea, vomiting, diarrhea, stomatitis, sore throat, chills, fever, rash, unusual bruising or bleeding, jaundice, dark urine, swelling of the extremities, or shortness of breath to their physician. Patients should also be counseled to avoid any other over-the-counter NSAID products.