actron and Iprivask Interactions

Interactions between actron(ketoprofen) and Iprivask (desirudin)

ketoprofen and desirudin (Major Drug-Drug)

GENERALLY AVOID: In patients receiving neuraxial anesthesia or spinal puncture, the risk of developing an epidural or spinal hematoma during selective thrombin inhibitor therapy may be increased by the concomitant use of other drugs that affect coagulation, including nonsteroidal anti-inflammatory drugs (NSAIDs) and platelet inhibitors. The development of epidural and spinal hematoma can lead to long-term or permanent paralysis.

MONITOR: Theoretically, coadministration of selective thrombin inhibitors with drugs that affect platelet function may potentiate the risk of bleeding due to additive or synergistic effects on hemostasis.

MANAGEMENT: Close clinical and laboratory observation for bleeding complications is recommended if selective thrombin inhibitors are used with drugs that interfere with platelet function. In patients undergoing neuraxial intervention, coadministration of these agents should be approached with caution and only after thorough assessment of risks and benefits. Besides bleeding complications, patients should also be monitored frequently for signs and symptoms of neurologic impairment such as midline back pain, sensory and motor deficits (numbness or weakness in lower limbs), and bowel or bladder dysfunction.