actonel and magnesium-trisilicate Interactions

You searched for interactions between:

• actonel
• magnesium-trisilicate (magnesium trisilicate)

Interaction(s) found:

magnesium trisilicate and risedronate (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to interfere with the gastrointestinal absorption of oral bisphosphonates. For example, the bioavailability of tiludronate has been shown to decrease 80% during simultaneous administration with calcium, and 60% when aluminum- or magnesium-containing antacids were administered one hour before tiludronate.

MANAGEMENT: Oral medications containing antacids (e.g., didanosine buffered tablets or pediatric oral solution), aluminum, calcium, magnesium and other polyvalent cations should be administered at least 30 minutes after the bisphosphonate dose.