Acetaminophen-propoxyphene-napsylate Drug Interactions

Acetaminophen-propoxyphene-napsylate is a multi-ingredient drug consisting of:

  • acetaminophen
  • propoxyphene

Interactions with each of its ingredients have been shown below:

acetaminophen is known to interact with the following drugs:

Click on a link below to view Drug-Drug Interactions with acetaminophen.

Major Interaction Major Interactions
alcohol, alcohol, ethyl, Dehydrated Alcohol, ethanol, Ethyl Alcohol

Moderate Interaction Moderate Interactions
Actidose-Aqua, Actidose-Aqua Advance, Activated Charcoal, Activated Charcoal with Sorbitol (obsolete), Active Carbon, amobarbital, Amytal Sodium, Anturane, Arava, Avonex, Avonex Prefilled Syringe, Betaseron, Brevital Sodium, Busodium, busulfan, Busulfex, butabarbital, butalbital, Butisol Sodium, carbamazepine, carbamazepine extended release, Carbatrol, Carbomix, Carbosorb X, Cerebyx, Char-Flo with Sorbitol (obsolete), Charcoaid, Charcoaid 2000, Charcoaid-G, charcoal, Charcoal Plus DS, Charcocaps, Charcodote, Charcodote (obsolete), Charcotabs, Charcotrace, Chem Mart Nasal Decongestant Capsule, clofarabine, Clolar, Di-Phen, Dilantin, Dilantin Infatabs, Dilantin Kapseals, Dilantin-125, echinacea, Epitol, Equetro, ethotoin, Eucarbon, EZChar, Folex PFS, fosphenytoin, Healthstream Activated Charcoal, INH, Insta-Char, interferon beta-1a, interferon beta-1b, isoniazid, J.L. Bragg's Medicinal Charcoal, Karbons, leflunomide, Liqui-Char, Liqui-Char with Sorbitol (obsolete), Luminal, Mebaral, Medicoal, mephenytoin, mephobarbital, Mesantoin, methohexital, methotrexate, Methotrexate Sodium, Preservative Free, Myleran, Mysoline, naltrexone, Nembutal, Nembutal Sodium, Norit, Nydrazid, Optimum Charcoal, Peganone, pentobarbital, Pentothal, Pharmacia Carbosorb, phenobarbital, Phenytek, phenytoin, phenytoin extended release, Phenytoin Sodium, Prompt, primidone, Ranexa, ranolazine, Rebif, ReVia, Rheumatrex Dose Pack, secobarbital, Seconal Sodium, Solfoton, sulfinpyrazone, Tegretol, Tegretol XR, thioguanine, thiopental, Trexall, Vivitrol

Minor Interaction Minor Interactions
A-Spas S/L, Akineton HCl, Anaspaz, anisindione, Artane, Atreza, AtroPen, atropine, AZT, belladonna, Belladonna Tincture, Benemid, Bentyl, benztropine, biperiden, Cantil, cholestyramine, Cholestyramine Light, cimetidine, clidinium, Cogentin, Corlopam, Coumadin, Cystospaz, Cystospaz-M, darifenacin, Detrol, Detrol LA, dicumarol, Dicyclocot, dicyclomine, diflunisal, Ditropan, Ditropan XL, Dolobid, Donnamar, Enablex, Estinyl, ethinyl estradiol, fenoldopam, flavoxate, glycopyrrolate, homatropine, HyoMax DT, HyoMax FT, HyoMax SL, HyoMax SR, hyoscyamine, hyoscyamine extended release, Hyosol, Hyospaz, Hyosyne, IB-Stat, Inderal, Inderal LA, InnoPran XL, Jantoven, Kemadrin, L-hyoscyamine, Levbid, Levsin, Levsin SL, Levsinex SR, Maldemar, mepenzolate, mestranol, methscopolamine, Miradon, Nulev, oxazepam, oxybutynin, oxybutynin extended release, Oxytrol, Pamine, Pamine Forte, Prevalite, Pro-Banthine, probenecid, procyclidine, propantheline, propranolol, propranolol extended release, Quarzan, Questran, Questran Light, ranitidine, ranitidine bismuth citrate, Regurin, Retrovir, Rifadin, Rifadin IV, rifampin, Rimactane, Robinul, Robinul Forte, Sal-Tropine, Sanctura, Sanctura XR, Scopace, scopolamine, scopolamine topical, Serax, sodium salicylate, solifenacin, Spasdel, Symax Duotab, Symax FasTab, Symax SL, Symax SR, Tagamet, Tagamet HB, tolterodine, tolterodine extended release, Transderm-Scop, Trihexane, trihexyphenidyl, Tritec, trospium, trospium extended release, Urispas, Urotrol, VESIcare, warfarin, Zantac, Zantac 150, Zantac 300, Zantac 300 GELdose, Zantac 75, Zantac EFFERdose, Zantac GELdose, zidovudine

propoxyphene is known to interact with the following drugs:

Click on a link below to view Drug-Drug Interactions with propoxyphene.

Major Interaction Major Interactions
40 Winks, 5-HTP, 5-hydroxytryptophan, Abilify, Abilify Discmelt, acetylcarbromal, Actiq, Adapin, Adgan, AHist, alcohol, alcohol, ethyl, Aler-Dryl, Aler-Tab, Aller-Chlor, Allergia-C, Allerhist-1, Allermax, alprazolam, alprazolam extended release, Altaryl, alvimopan, Ambien, Ambien CR, amitriptyline, amobarbital, amoxapine, Amrix, Amytal Sodium, Anafranil, Anergan 50, Antiflex, Antinaus 50, Antivert, APO-Go, APO-Go Pen, Apokyn, apomorphine, Aquachloral Supprettes, aripiprazole, Asendin, Astramorph PF, Atapryl, Atarax, Ativan, Aventyl HCl, Avinza, azatadine, Azilect, B-Vex, baclofen, Banaril, Banflex, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Child Dye Free, Benadryl Childrens Allergy Fastmelt, Benadryl DF, Benadryl Dye Free Allergy, Benadryl Ultratab, Benahist-10, Benahist-50, Benoject-50, Benzacot, Bidhist, Bonine, Bromaphen, bromocriptine, bromodiphenhydramine, brompheniramine, brompheniramine extended release, BroveX, BroveX CT, Budeprion SR, Budeprion XL, Buprenex, buprenorphine, buPROPion, buPROPion 24 hour extended release, buPROPion extended release, Busodium, BuSpar, BuSpar Dividose, busPIRone, butabarbital, butalbital, Butisol Sodium, butorphanol, butorphanol nasal, Bydramine, C.P.M., cabergoline, Calm-Aid, Carbacot, Carbex, carbinoxamine, carbinoxamine extended release, Carbinoxamine PD, Carboxine, carisoprodol, Catapres, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3, Celexa, Celontin, Cerebyx, Cesamet, Chem Mart Tramadol, Chlo-Amine, Chlor-Al Rel, Chlor-Mal, Chlor-Phen, Chlor-Phenit, Chlor-Trimeton, Chlor-Trimeton Allergy SR, chloral hydrate, chlordiazepoxide, chlormezanone, Chlorphen, chlorphenesin, chlorpheniramine, Chlorpheniramine (Allergy), chlorpheniramine 24 hour extended release, chlorpheniramine extended release, chlorproMAZINE, chlorproMAZINE extended release, ChlorTan, chlorzoxazone, citalopram, clemastine, clomiPRAMINE, clonazepam, clonidine, clonidine topical, Clopine, clorazepate, clorazepate extended release, clozapine, Clozapine Synthon, Clozaril, codeine, codeine phosphate, codeine sulfate, Codimal A, Comfort Pac with Cyclobenzaprine, Compazine, Compazine Spansule, Compoz Nighttime Sleep Aid, Compro, Comtan, Contac 12 Hour Allergy, Cophene B, Cordron NR, cyclizine, cyclobenzaprine, cyclobenzaprine extended release, Cymbalta, cyproheptadine, D-Vert, Dailyhist-1, Dalgan, Dalmane, Dantrium, Dantrium Intravenous, dantrolene, Dazidox, Dehydrated Alcohol, Demerol HCl, Denzapine, Depacon, Depakene, Depakote, Depakote ER, Depakote Sprinkles, DepoDur, desipramine, desvenlafaxine, Desyrel, Desyrel Dividose, dexbrompheniramine, dexchlorpheniramine, dexchlorpheniramine extended release, dexmedetomidine, dezocine, Di-Phen, Diastat, Diastat AcuDial, Diastat Pediatric, diazepam, dichloralphenazone, dihydrocodeine, Dilantin, Dilantin Infatabs, Dilantin Kapseals, Dilantin-125, Dilaudid, Dilaudid-5, Dilaudid-HP, dimenhyDRINATE, Dimetane, Dimetane Extentab, Dimetapp Allergy, Dimetapp Allergy Liquigel, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, diphenhydrAMINE, diphenhydrAMINE citrate, diphenhydrAMINE tannate, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Diskets, divalproex sodium, divalproex sodium extended release, Dizac, DMH, Dolophine, Doloral, Doloral Sirop, Dopar, Doral, Dostinex, doxepin, doxepin topical, doxylamine, DPH, Dramamine, Dramamine II, Dramoject, Driminate, Driminate II, Dromadol SR, Dromadol XL, dronabinol, droperidol, duloxetine, Duraclon, Duragesic, Duragesic-100, Duragesic-12, Duragesic-25, Duragesic-50, Duragesic-75, Duramorph PF, Dymenate, Dytan, Dytuss, Ed Chlor-Tan, Ed ChlorPed, Effexor, Effexor XR, Efidac-24 Chlorpheniramine, Elavil, Eldepryl, Emsam, Endep, Endocodone, entacapone, Entereg, Equanil, escitalopram, Eskalith, Eskalith-CR, estazolam, eszopiclone, ETH-Oxydose, ethanol, ethchlorvynol, ethosuximide, ethotoin, Ethyl Alcohol, Eze D.S., FazaClo, felbamate, Felbatol, fentanyl, fentanyl topical, Fentora, Fexmid, flavoxate, Flexeril, Flexoject, Flexon, fluoxetine, fluoxetine extended release, fluphenazine, fluphenazine decanoate, fluphenazine enanthate, fluphenazine hydrochloride, flurazepam, fluvoxamine, fluvoxamine extended release, fosphenytoin, furazolidone, Furoxone, gabapentin, Gabarone, Gabitril, Genahist, GenRx Tramadol, Geodon, GHB, halazepam, Halcion, Haldol, Haldol Decanoate, haloperidol, haloperidol decanoate, Histaject, Histex CT, Histex I/E, Histex PD, Histex Pd 12, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hydrate, hydrocodone, Hydromorph Contin, hydromorphone, hydromorphone extended release, Hydrostat IR, hydrOXYzine, hydrOXYzine hydrochloride, hydrOXYzine pamoate, hypericum perforatum, Hyrexin, Hyzine, imipramine, imipramine pamoate, Inapsine, Infumorph, Invega, iohexol, Ionsys, iopamidol, Iopamidol-370, isocarboxazid, Isovue-128, Isovue-200, Isovue-250, Isovue-300, Isovue-370, Isovue-M-200, Isovue-M-300, J-Tan, J-Tan PD, Jumex, Kadian, Keppra, Ketalar, ketamine, Klonopin, Klonopin Wafer, l-tryptophan, Lamictal, Lamictal Blue, Lamictal CD, Lamictal Green, Lamictal Orange, lamotrigine, Larapam SR, Largon, Larodopa, levetiracetam, Levo-Dromoran, levodopa, Levoprome, levorphanol, Lexapro, Librium, Lioresal, Lioresal Intrathecal, lithium, lithium carbonate, lithium carbonate extended release, lithium citrate, Lithobid, Lithonate, Lithotabs, Lodrane 12 Hour, Lodrane 24, Lodrane XR, lorazepam, loxapine, Loxitane, Loxitane C, Loxitane IM, Ludiomil, Luminal, Lunesta, Luvox, Luvox CR, Lyrica, M-Eslon, M-Oxy, M. O. S., Maldemar, Maolate, maprotiline, Marezine, Marinol, Marplan, Matulane, MB-TAB, Mebaral, Meclicot, meclizine, Medivert, Mellaril, Mellaril-S, Meni-D, meperidine, mephenytoin, mephobarbital, meprobamate, Meridia, Mesantoin, mesoridazine, metaxalone, methadone, Methadose, methdilazine, methocarbamol, methotrimeprazine, methsuximide, metoclopramide, metrizamide, midazolam, Milontin, Miltown, Mio-Rel, Mirapex, mirtazapine, Mitran, Moban, molindone, morphine, morphine 24 hour extended release, morphine extended release, Morphine IR, morphine liposomal, Morphine LP Epidural, morphine preservative-free, Morphine Rapi-Ject, Morphitec, MS, MS Contin, MS/S, MSIR, Myelo-Kit, Myolin, Mysoline, nabilone, nalbuphine, Nardil, Nasahist B, Navane, ND-Stat, nefazodone, Nembutal, Nembutal Sodium, Nervine, Neupro, Neurontin, Nightime Sleepaid, Niravam, Nolahist, Norflex, Norflex Injectable, Norpramin, nortriptyline, Nu-Med, Nubain, Numorphan HCl, Nytol Caplet, Nytol Maximum Strength, olanzapine, Omnipaque 140, Omnipaque 180, Omnipaque 180 Redi-Unit, Omnipaque 210, Omnipaque 240, Omnipaque 240 Redi-Unit, Omnipaque 300, Omnipaque 350, Omnipaque Flexipak, OMS, Opana, Opana ER, opium, Opium Deodorized, Optimine, Oramorph SR, Orap, Orfro, Ormazine, orphenadrine, orphenadrine extended release, Orphenate, oxazepam, oxcarbazepine, oxycodone, oxycodone extended release, OxyContin, Oxyfast, OxyIR, oxymorphone, oxymorphone extended release, P-Tann, P-Tex, Palgic, paliperidone, Palladone, Palladone SR, Pamelor, Paradione, Paraflex, Parafon Forte DSC, Paral, paraldehyde, paramethadione, Pardryl, Paregoric, Parlodel, Parnate, paroxetine, paroxetine extended release, paroxetine mesylate, Paxarel, Paxil, Paxil CR, PBZ, PBZ-SR, PediaTan, Pediatex, Pediatex 12, Pediox, Pediox-S, Peganone, Pentazine, pentazocine, pentobarbital, Percolone, pergolide, Periactin, Permax, Permitil, perphenazine, Pexeva, phenacemide, Phenadoz, Phenazine 50, phenelzine, Phenergan, Phenergan Fortis, phenindamine, pheniramine, phenobarbital, Phenoject-50, phensuximide, Phenurone, phenyltoloxamine, Phenytek, phenytoin, phenytoin extended release, Phenytoin Sodium, Prompt, pimozide, Placidyl, Polaramine, Polaramine Repetabs, pramipexole, Precedex, pregabalin, Prialt, primidone, Pristiq, Pro-Med, procarbazine, prochlorperazine, prochlorperazine extended release, Procot, Prolixin, Prolixin Decanoate, Prolixin Enanthate, Promacot, promazine, promethazine, Promethegan, Prop-A-Tane, propiomazine, Prorex, Prosom, protriptyline, Prozac, Prozac Weekly, Prudoxin, pyrilamine, pyrilamine extended release, Pyrlex, Q-Dryl, Q-Dryl A/F, QDALL AR, quazepam, Quenalin, quetiapine, quetiapine extended release, ramelteon, Rapiflux, rasagiline, Reglan, Relaxazone, Remeron, Remeron SolTab, Remular, Remular-S, Repreve, Requip, ReQuip Follow on Pack, Requip Starter Kit, ReQuip Starter Pack, Requip XL, Rescudose, Restoril, Rezine, Ridramin, Risperdal, Risperdal Consta, Risperdal M-Tab, risperidone, RMS, Robaxin, Robaxin-750, Rohist, ropinirole, ropinirole extended release, rotigotine, Roxanol, Roxanol 100, Roxanol-T, Roxicodone, Roxicodone Intensol, Rozerem, Ru-Vert-M, Sarafem, Scopace, scopolamine, scopolamine topical, Scot-Tussin Allergy Relief Formula, secobarbital, Seconal Sodium, selegiline, Selfemra, Selgene, Serax, Serentil, Seroquel, Seroquel XR, sertraline, Serzone, sibutramine, Siladryl, Siladryl Allergy, Siladryl DAS, Siladyl SA, Silphen Cough, Siltane, Simply Sleep, Sinequan, Skelaxin, Skelex, Sleep Tab II, Sleep Tabs, Sleep-ettes, Sleep-ettes D, Sleep-Eze-3, Sleepinal, sodium biphosphate, sodium oxybate, sodium valproate, Solfoton, Soma, Sominex, Sominex Maximum Strength Caplet, Somnicaps, Somnote, Sonata, Sparine, St. John's wort, Stadol, Stadol NS, Statex, Stavzor, Stelazine, Strifon Fort, Sublimaze, Subutex, Surmontil, Tacaryl, Talwin Lactate, Tanacof-XR, TanaHist-PD, Tasmar, Tavist, Tavist Allergy, Tavist-1, Temaril, temazepam, Terry White Chemists Tramadol, thalidomide, Thalomid, Theraflu Thin Strips Multi Symptom, thiethylperazine, thioridazine, thiothixene, Thorazine, tiagabine, Ticon, Tigan, tizanidine, Tofranil, Tofranil-PM, tolcapone, Topamax, Topamax Sprinkle, topiramate, Torecan, Total Allergy, traMADOL, traMADOL extended release, Tramahexal, Tramahexal SR, Tramake, Tramake Insts, Tramal, Tramal SR, Tramedo, Trancopal, Transderm-Scop, Tranxene SD, Tranxene T-Tab, tranylcypromine, traZODONE, Triaminic Allergy, Triaminic Thin Strips Cough & Runny Nose, triazolam, Tridione, trifluoperazine, triflupromazine, Trilafon, Trileptal, trimeprazine, trimethadione, trimethobenzamide, trimipramine, tripelennamine, Tripohist, triprolidine, triprolidine extended release, Triptone, Truxadryl, Tryptan, tryptophan, Tusstat, Twilite, Ultram, Ultram ER, Uni-Tann, Unisom, Unisom Sleepgels Maximum Strength, Uprima, Urispas, V-Gan-25, V-Gan-50, Valium, valproic acid, Valrelease, Valu-Dryl, Vanadom, Vanatrip, VaZol, venlafaxine, venlafaxine extended release, Versed, Vistacon, Vistacot, Vistaject-50, Vistaril, Vistaril IM, Vistazine, Vistazine 50, Vivactil, Wal-finate, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Xanax, Xanax XR, Xyrem, zaleplon, Zamadol, Zamadol 24hr, Zamadol Melt, Zamadol SR, Zanaflex, Zaponex, Zarontin, Zelapar, Zetran, ziconotide, ziprasidone, Zoloft, zolpidem, zolpidem extended release, Zonalon, Zonegran, zonisamide, Zyban, Zyban Advantage Pack, Zydol, Zydol SR, Zydol XL, Zymine, Zymine XR, Zyprexa, Zyprexa Zydis

Moderate Interaction Moderate Interactions
A-Spas S/L, Accupril, acebutolol, Aceon, acetoHEXAMIDE, Actidose-Aqua, Actidose-Aqua Advance, activated attapulgite, Activated Charcoal, Activated Charcoal with Sorbitol (obsolete), Active Carbon, Adalat, Adalat CC, Afeditab CR, Akineton HCl, Aldactone, Alfenta, alfentanil, Alphagan, Alphagan P, Altace, Amaryl, amiloride, amlodipine, amyl nitrite, Anaspaz, anisindione, Apidra, Apidra OptiClik Cartridge, apraclonidine ophthalmic, Apresoline, Aquazide H, Arfonad, Artane, Atacand, atenolol, atomoxetine, Atreza, AtroPen, atropine, attapulgite, Avapro, belladonna, Belladonna Tincture, bendroflumethiazide, Benicar, Bentyl, benzthiazide, benztropine, Betapace, Betapace AF, Betapace AF(obsolete), betaxolol, Betimol, biperiden, Bismarex, Bismatrol, Bismatrol Maximum Strength, bismuth subgallate, bismuth subnitrate, bismuth subsalicylate, bisoprolol, Blocadren, Brevibloc, Brevital Sodium, brimonidine ophthalmic, Bystolic, Calan, Calan SR, candesartan, Cantil, Capoten, captopril, carbamazepine, carbamazepine extended release, Carbatrol, Carbomix, Carbosorb X, Cardene, Cardene IV, Cardene SR, Cardizem, Cardizem CD, Cardizem LA, Cardizem Monovial, Cardizem SR, Carozide, Cartia XT, carvedilol, carvedilol extended release, Celebrex, celecoxib, cevimeline, Char-Flo with Sorbitol (obsolete), Charcoaid, Charcoaid 2000, Charcoaid-G, charcoal, Charcoal Plus DS, Charcocaps, Charcodote, Charcodote (obsolete), Charcotabs, Charcotrace, Chem Mart Nasal Decongestant Capsule, Childrens Kaopectate, chlorproPAMIDE, chlorthalidone, cimetidine, cinacalcet, clidinium, Cogentin, Compound 374, Coreg, Coreg CR, Corgard, Coumadin, Covera-HS, Cozaar, Cystospaz, Cystospaz-M, darifenacin, Demadex, Demadex I.V., Deponit, desflurane, Detrol, Detrol LA, DiaBeta, Diabinese, Diamode, Diaqua, Diaqua-2, Diar-Aid, diazoxide, Dibenzyline, dicumarol, Dicyclocot, dicyclomine, difenoxin, Dilacor XR, Dilatrate-SR, Diltia XT, diltiazem, diltiazem 24 hour extended release, diltiazem extended release, Diltiazem Hydrochloride CD, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride XR, Diltiazem Hydrochloride XT, Diovan, diphenoxylate, Diprivan, Ditropan, Ditropan XL, Diucardin, Donnagel, Donnamar, Dymelor, Dynacirc, Dynacirc CR, Dyrenium, Enablex, enalapril, enalaprilat, enflurane, Epitol, eprosartan, Equetro, Esidrix, esmolol, Ethrane, Eucarbon, Evoxac, Exna, EXUBERA, EXUBERA Combination Pack 12, EXUBERA Combination Pack 15, EXUBERA Kit, EZChar, Ezide, felodipine, felodipine extended release, Fluothane, Forane, fosinopril, furosemide, galantamine, galantamine extended release, glimepiride, glipiZIDE, glipiZIDE extended release, GlipiZIDE XL, Glucotrol, Glucotrol XL, glyBURIDE, glyBURIDE micronized, Glynase PresTab, guanethidine, halothane, HCTZ, Healthstream Activated Charcoal, Humalog, Humalog Cartridge, Humalog KwikPen, Humalog Pen, Humulin L, Humulin N, Humulin N Pen, Humulin R, Humulin R (Concentrated), Humulin U, hydrALAZINE, Hydro Par, hydrochlorothiazide, HydroDIURIL, hydroflumethiazide, Hygroton, HyoMax DT, HyoMax FT, HyoMax SL, HyoMax SR, hyoscyamine, hyoscyamine extended release, Hyosol, Hyospaz, Hyosyne, Hyperstat, IB-Stat, Iletin II Lente Pork, Iletin II NPH Pork, Iletin II Regular Pork, Iletin Lente, Iletin NPH, Iletin Regular, Imdur, Imodium, Imodium A-D, Imodium A-D EZ Chews, Imodium A-D New Formula, Imotil, indapamide, Inderal, Inderal LA, InnoPran XL, Insta-Char, insulin, insulin analog, insulin aspart,