Drug interactions between acetaminophen/pentazocine and Alcohol (contained in alcoholic beverages)
| Results for the following 2 drugs: |
|---|
| acetaminophen/pentazocine |
| Alcohol (contained in alcoholic beverages) (ethanol) |
Interactions between your selected drugs
acetaminophen ↔ ethanol
Applies to:acetaminophen/pentazocine and Alcohol (contained in alcoholic beverages) (ethanol)
GENERALLY AVOID: Chronic, excessive consumption of alcohol may increase the risk of acetaminophen-induced hepatotoxicity, which has included rare cases of fatal hepatitis and frank hepatic failure requiring liver transplantation. The proposed mechanism is induction of hepatic microsomal enzymes during chronic alcohol use, which may result in accelerated metabolism of acetaminophen and increased production of potentially hepatotoxic metabolites.
MANAGEMENT: In general, chronic alcoholics should avoid regular or excessive use of acetaminophen. Alternative analgesic/antipyretic therapy may be appropriate in patients who consume three or more alcoholic drinks per day. However, if acetaminophen is used, these patients should be cautioned not to exceed the recommended dosage (maximum 4 g/day in adults and children 12 years of age or older).
pentazocine ↔ ethanol
Applies to:acetaminophen/pentazocine and Alcohol (contained in alcoholic beverages) (ethanol)
GENERALLY AVOID: The central nervous system-depressant effects of opioid analgesics and ethanol may be additive. The combination of these agents may result in additive CNS-depression and impairment of judgment, thinking, and psychomotor skills. In more severe cases, respiratory depression, hypotension, profound sedation, and coma can occur. Death has been reported in overdosage.
MANAGEMENT: The concomitant use of opioid analgesics and ethanol should be avoided.
See also...
- Acetaminophen/pentazocine Drug Interactions
- acetaminophen and pentazocine General Consumer Information
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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