Drug interactions between acetaminophen/hydrocodone and Epitol
Results for the following 2 drugs: |
|
|---|---|
| acetaminophen/hydrocodone | |
| Epitol (carbamazepine) | |
Interactions between your selected drugs
acetaminophen ⇔ carbamazepine
Applies to: acetaminophen/hydrocodone and Epitol (carbamazepine)
MONITOR: Limited data suggest that carbamazepine may increase the potential hepatotoxicity of acetaminophen and decrease its pharmacologic effects. The mechanism may be related to accelerated CYP450 metabolism of acetaminophen with consequent increase of hepatotoxic metabolites. This interaction is of greatest concern in cases of acetaminophen overdose.
MANAGEMENT: Until more information is available, the use of this combination over a prolonged period of time should probably be avoided. Monitoring for clinical and laboratory evidence of hepatotoxicity is recommended.
carbamazepine ⇔ hydrocodone
Applies to: Epitol (carbamazepine) and acetaminophen/hydrocodone
MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.
MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
See also...
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