Skip to Content
Diagnosed with ankylosing spondylitis? Biologics can help >>

Vicodin ES (acetaminophen / hydrocodone) Drug Interactions

A total of 743 drugs (4233 brand and generic names) are known to interact with Vicodin ES (acetaminophen / hydrocodone).
  • 203 major drug interactions (1129 brand and generic names)
  • 504 moderate drug interactions (2785 brand and generic names)
  • 36 minor drug interactions (319 brand and generic names)

Show all medications in the database that may interact with Vicodin ES (acetaminophen / hydrocodone).

Check for interactions with Vicodin ES (acetaminophen / hydrocodone)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Vicodin ES (acetaminophen / hydrocodone)

You should also know about...

Vicodin ES (acetaminophen / hydrocodone) alcohol/food Interactions

There are 2 alcohol/food interactions with Vicodin ES (acetaminophen / hydrocodone)

Vicodin ES (acetaminophen / hydrocodone) disease Interactions

There are 19 disease interactions with Vicodin ES (acetaminophen / hydrocodone) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.