Drug interactions between Abilify and Prozac
| Results for the following 2 drugs: |
|---|
| Abilify (aripiprazole) |
| Prozac (fluoxetine) |
Interactions between your selected drugs
fluoxetine ↔ aripiprazole
Applies to:Prozac (fluoxetine) and Abilify (aripiprazole)
ADJUST DOSE: Coadministration with quinidine or other potent inhibitors of CYP450 2D6 may significantly increase the plasma concentrations of aripiprazole, which is partially metabolized by the isoenzyme. According to the product labeling, administration of aripiprazole (10 mg single dose) following pretreatment with quinidine (166 mg/day for 13 days) resulted in a 112% increase in aripiprazole systemic exposure (AUC) compared to administration of aripiprazole alone. The AUC of its active metabolite, dehydro-aripiprazole, was decreased by 35% in the presence of quinidine.
MANAGEMENT: Pharmacologic response to aripiprazole should be monitored more closely whenever quinidine or other potent inhibitors of CYP450 2D6 (e.g., fluoxetine, paroxetine, cinacalcet) are added to or withdrawn from therapy. The manufacturer recommends that aripiprazole dosage be reduced to one-half the normal dosage during concomitant administration with quinidine, and additional dosage adjustments be made based on clinical evaluation. Although clinical data are lacking, similar dosage adjustments may be appropriate during coadministration with other potent CYP450 2D6 inhibitors. Aripiprazole dosage should be increased accordingly if these agents are discontinued.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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