Drug interactions between Abilify and oxcarbazepine
Results for the following 2 drugs: |
|
|---|---|
| Abilify (aripiprazole) | |
| oxcarbazepine | |
Interactions between your selected drugs
oxcarbazepine ⇔ aripiprazole
Applies to: oxcarbazepine and Abilify (aripiprazole)
MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of aripiprazole, which is partially metabolized by the isoenzyme. According to the product labeling, administration of aripiprazole (30 mg once a day) with the potent CYP450 3A4 inducer carbamazepine (200 mg twice a day) resulted in an approximately 70% decrease in the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of aripiprazole and its active metabolite, dehydro-aripiprazole.
MANAGEMENT: Pharmacologic response to aripiprazole should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the aripiprazole dosage adjusted as necessary. The manufacturer recommends that aripiprazole dosage be doubled when carbamazepine is added to therapy, and additional dosage increases be based on clinical evaluation. No dosage recommendations are available for concomitant administration with other CYP450 3A4 inducers.
See also...
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2009 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
