Drug interactions between Abilify and Noxafil
Results for the following 2 drugs: |
|
|---|---|
| Abilify (aripiprazole) | |
| Noxafil (posaconazole) | |
Interactions between your selected drugs
aripiprazole ⇔ posaconazole
Applies to: Abilify (aripiprazole) and Noxafil (posaconazole)
ADJUST DOSE: Coadministration with ketoconazole or other potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of aripiprazole, which is partially metabolized by the isoenzyme. According to the product labeling, ketoconazole (200 mg/day for 14 days) increased the area under the plasma concentration-time curve (AUC) of aripiprazole (15 mg single dose) and its active metabolite, dehydro-aripiprazole, by 63% and 77%, respectively, compared to administration of aripiprazole alone. The effect of a higher dosage of ketoconazole has not been studied.
MANAGEMENT: Pharmacologic response to aripiprazole should be monitored more closely whenever ketoconazole or other potent inhibitors of CYP450 3A4 (e.g., itraconazole, nefazodone, certain protease inhibitors) are added to or withdrawn from therapy. The manufacturer recommends that aripiprazole dosage be reduced to one-half the normal dosage during concomitant administration with ketoconazole, and additional dosage adjustments be based on clinical evaluation. Similar dosage adjustments should be made during coadministration with other potent CYP450 3A4 inhibitors. Aripiprazole dosage should be increased accordingly if these agents are discontinued.
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