Tricyclic antidepressants

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Tricyclic antidepressants (TCAs) act by inhibiting reuptake of norepinephrine and serotonin by blocking the transporters responsible for reuptake of these neurotransmitters. This inhibition elevates the concentration of neurotransmitters in the synapses and triggers further neurotransmission.

Tricyclic antidepressants are used to treat depression, bipolar disorder, anxiety, obsessive-compulsive disorder and other mood disorders. They are also effective as analgesics so are used to treat chronic pain and used for migraine prophylaxis.

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