Prostaglandin D2 antagonists

Prostagladin D2 antagonists are used to treat or prevent prostagladin D2 mediated conditions such as allergic disorders including allergic asthma, allergic rhinitis and atopic dermatitis.

Prostaglandin D2 is a chemical mediator important in the development of allergic disease and causes the characteristic symptoms of allergy. Prostagladin D2 is produced when there is IgE-dependant activation of mast cell by antigens and once produced it recruits eosinophil, basophils and Th2 which cause the symptoms of allergy. The prostaglandin D2 antagonist blocks the prostaglandin D2 which stops the chemical mediators pathway and therefore reduces allergy symptoms.