Home Drug Classes Anti-infectives Antiviral Agents Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

Nucleoside reverse transcriptase inhibitors (NRTIs)

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Nucleoside reverse transcriptase inhibitors (NRTIs) are active inhibitors of reverse transcriptase found in retroviruses such as the human immunodeficiency virus (HIV). The different nucleoside reverse transcriptase inhibitors may be activated differently but they have the same mechanism of action. NRTIs are activated generally by phosphorylation to the triphosphate form by cellular enzymes. It then competes with cellular triphosphates, which are substrates for proviral DNA by viral reverse transcriptase. NRTI

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adefovir systemic (Pro, More...)
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entecavir systemic (Pro, More...)
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lamivudine systemic (Pro, More...)
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zidovudine systemic (Pro, More...)
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See also

Medical conditions associated with nucleoside reverse transcriptase inhibitors (NRTIs):

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