Nonsteroidal anti-inflammatory agents

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

All nonsteroidal anti-inflammatory agents (NSAIDs) differ in structure but they all have similar antipyretic, anti-inflammatory and analgesic properties.

NSAIDs work by blocking the cyclo-oxygenase (COX) enzyme, so inhibit production of prostaglandins and thromboxanes, which are produced as part of the inflammatory response.

There are two types of COX enzymes, COX-1 and COX-2. COX-1 is expressed in most tissues, including platelets. COX-2 is induced in inflammatory cells when they are activated and the primary inflammatory cytokines (interleukin-1 and tumor necrosis factor alpha). COX-2 enzyme is responsible for production of mediators of inflammation. Most NSAIDs are inhibitors of both isoenzymes. The anti-inflammatory action of NSAIDs is mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1.

There can be considerable variation in individual patient response and tolerance to different NSAIDs.

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Drug Name DownUp( View by: Brand | Generic ) Reviews Ratings DownUp
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fenoprofen systemic (Pro, More...)
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indomethacin systemic (Pro, More...)
66 reviews
   
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diclofenac systemic (Pro, More...)
234 reviews
   
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ketorolac systemic (Pro, More...)
125 reviews
   
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etodolac systemic (Pro, More...)
24 reviews
   
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ibuprofen systemic (Pro, More...)
67 reviews
   
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meloxicam systemic (Pro, More...)
165 reviews
   
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naproxen systemic (Pro, More...)
207 reviews
   
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7.3
mefenamic acid systemic (Pro, More...)
19 reviews
   
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7.0
flurbiprofen systemic (Pro, More...)
6 reviews
   
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6.9
nabumetone systemic (Pro, More...)
40 reviews
   
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6.9
oxaprozin systemic (Pro, More...)
7 reviews
   
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6.1
famotidine / ibuprofen systemic (Pro, More...)
2 reviews
   
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5.7
lansoprazole / naproxen systemic (More...)
0 reviews
   
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0.0
meclofenamate systemic (Pro, More...)
0 reviews
   
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0.0
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