Leukotriene modifiers

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Leukotriene modifiers prevent the action of leukotrienes in the body. Leukotrienes are released from mast cells, basophils and eosinophils. The release of leukotrienes causes airway constriction, increased mucus production, swelling and inflammation in the lungs. This presents as wheezing, shortness of breath in asthma.

Leukotriene modifiers include two types of agents:

Leukotriene-receptor antagonists prevent leukotrienes from binding to its receptors

Leukotriene synthesis inhibitors prevent synthesis of leukotrienes by blocking the enzyme, 5-lipoxygenase, which is necessary for the formation of leukotrienes.

Leukotriene modifiers are used to treat and prevent chronic asthma and allergic rhinitis. Generally they are used in combination with inhaled corticosteroids for best results.

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See also...

Medical conditions associated with leukotriene modifiers:

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