Hedgehog pathway inhibitors

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

The Hedgehog pathway plays an essential role in cell growth and differentiation in the developing embryo. It is typically silenced in adult tissues. In postembryonic life, the pathway may be activated to stimulate tissue repair or cell proliferation. Abnormal activation may lead to cancer, including basal cell carcinoma. Hedgehog pathway inhibitors target the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors. Hedgehog pathway inhibitors may be used to treat basal cell carcinoma that has spread to other parts of the body.

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Medical conditions associated with hedgehog pathway inhibitors:

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