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Gonadotropin-releasing hormone antagonists

What are Gonadotropin-releasing hormone antagonists?

*Gonadotropin-releasing hormone (GnRH) antagonists are synthetic analogs of gonadotropin-releasing hormone, which is produced by the hypothalamus and controls the secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary. Gonadotropin-releasing hormone antagonists bind to gonadotropin-releasing hormone receptors and decrease the effect of gonadotropin-releasing hormone.

In men, gonadotropin-releasing hormone antagonists inhibit the release of luteinizing hormone, and consequently less testosterone is produced. Testosterone stimulates the growth of many forms of prostate cancer. Gonadotropin-releasing hormone antagonists are used to treat prostate cancer as by reducing the levels of testosterone the size of prostate cancer is reduced.

Gonadotropin-releasing hormone antagonists are used to treat women undergoing fertility treatment. It prevents early release of luteinizing hormone (LH) and premature ovulation in women being administered follicle-stimulating hormone (FSH) when preparing for in-vitro fertilization.

List of Gonadotropin-releasing hormone antagonists

View by  Brand | Generic
Drug Name Avg. Rating Reviews
cetrorelix systemic (Pro)
No reviews
ganirelix systemic (Pro)
No reviews
degarelix systemic (Pro)
8.8
12 reviews
relugolix systemic (Pro)
7.7
17 reviews
elagolix systemic (Pro)
5.3
127 reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

See also

Medical conditions treated or associated with gonadotropin-releasing hormone antagonists:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.