A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.
Bisphosphonates are drugs that inhibit mineralization or resorption of the bone by blocking the action of osteoclasts. Bisphosphonates are enzyme-resistant analogues of pyrophosphate, which normally inhibits mineralization in the bone. Their effect is dose dependent and they reduce the turnover of bone by inhibiting recruitment and promoting apoptosis of osteoclasts.
Bisphosphonates are used to treat postmenopausal and glucocorticoid induced osteoporosis, Paget
Medical conditions associated with bisphosphonates:
- Aseptic Necrosis
- Breast Cancer, Bone Metastases
- Heterotopic Ossification, Spinal Cord Injury
- Heterotopic Ossification, Total Hip Arthroplasty
- Hypercalcemia of Malignancy
- Osteolytic Bone Lesions of Multiple Myeloma
- Osteolytic Bone Metastases of Solid Tumors
- Paget's Disease
- Prevention of Osteoporosis