Zileuton Dosage

Medically reviewed by Drugs.com. Last updated on Nov 21, 2023.

Applies to the following strengths: 600 mg

Usual Adult Dose for Asthma - Maintenance

Immediate Release:

Extended Release:

Comments:

Immediate release tablets may be taken with meals and at bedtime.
Assess hepatic function enzymes prior to initiating this drug and periodically during treatment.

Use: Prophylaxis and chronic treatment of asthma

Less than 12 years: Not recommended.

12 years or older:

Immediate Release: 600 mg orally four times a day
Extended Release: 1200 mg orally twice a day, within one hour after morning and evening meals
Maximum daily dose: 2400 mg

Comments:

Immediate release tablets may be taken with meals and at bedtime.
Assess hepatic function enzymes prior to initiating this drug and periodically during treatment.

Use: Prophylaxis and chronic treatment of asthma

No adjustment recommended.

Active liver disease or persistent hepatic transaminase elevations greater than or equal to 3 times the upper limit of normal (ULN): Contraindicated

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Hemodialysis: No adjustment recommended.
Peritoneal dialysis: Data not available

Administration advice:

Immediate-release tablets can be taken with or without food.
Extended-release tablets should be taken within one hour after morning and evening meals; tablets should not be chewed, cut or crushed.
If a dose is missed, the next dose should be taken at the scheduled time; dose should not doubled.
Assess hepatic function enzymes prior to initiating this drug and monitor periodically during treatment.

General:

Monitoring:

Patient advice:

Immediately report any symptoms of hepatic dysfunction (e.g., right upper quadrant, pain, nausea, fatigue, lethargy, pruritus, jaundice, flu-like symptoms, and anorexia).
This drug is indicated for the chronic treatment of asthma and should be taken regularly as prescribed, even during symptom-free periods.
Patients should not decrease the dose of this drug or stop taking any other antiasthma medications unless instructed by a physician.
The physician should be notified if neuropsychiatric events occur while using this drug.
This drug can interact with other drugs; therefore, patients should consult their doctors before starting or stopping any prescription or non-prescription medicines.