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Vardenafil Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Erectile Dysfunction

10 mg orally as oral tablet or oral disintegrating tablet administered as needed 1 hour prior to anticipated sexual activity. A maximum of one dose per day is recommended. Sexual stimulation is required for response to treatment.

Usual Geriatric Dose for Erectile Dysfunction

5 mg orally as needed 1 hour prior to anticipated sexual activity. Sexual stimulation is required for response to treatment.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

In patients with moderate hepatic impairment (Child-Pugh B), the starting dose is 5 mg orally as needed 1 hour prior to anticipated sexual activity. The maximum dose should not exceed 10 mg.

Dose Adjustments

The dose may be increased to a maximum recommended dose of 20 mg or decreased to 5 mg depending on efficacy and side effects. A maximum of one dose per day is recommended.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Vardenafil at recommended doses has no effect in the absence of sexual stimulation.

Vardenafil potentiates the hypotensive effect of concurrently administered nitrates, therefore patients receiving nitrate therapy should be advised to use an alternate treatment for erectile dysfunction.

Some patients receiving vardenafil may experience a transient visual disturbance which makes objects appear to have a blue tint or creates difficulty distinguishing the difference between the colors blue and green. While the efficacy of sildenafil in treating erectile dysfunction is associated with its competitive inhibition of phosphodiesterase type 5 causing the release of nitric oxide in the blood vessels of the corpus cavernosum, higher doses may cause a transient inhibition of phosphodiesterase 6 located in the retina, resulting in altered blue/green color discrimination.

Vardenafil is metabolized in the liver by the cytochrome 450 enzyme system, therefore, drugs which are inhibitors or inducers of this system should be expected to alter levels of vardenafil when given concomitantly.

Caution should be exercised when prescribing vardenafil to patients with underlying cardiovascular disease, particularly patients with long QT syndrome.

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