Tinidazole Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Trichomoniasis

2 g orally once with food
The sexual partners should be treated with the same dose at the same time.

Usual Adult Dose for Giardiasis

2 g orally once with food

Usual Adult Dose for Amebiasis

Intestinal: 2 g orally once a day with food for 3 days
Amebic liver abscess: 2 g orally once a day with food for 3 to 5 days

Usual Adult Dose for Bacterial Vaginosis

Nonpregnant, adult women: 2 g orally once a day with food for 2 days or 1 g orally once a day with food for 5 days

Usual Pediatric Dose for Trichomoniasis

2 g orally once with food
The sexual partners should be treated with the same dose at the same time.

Usual Pediatric Dose for Giardiasis

3 years or older: 50 mg/kg (up to 2 g) orally once with food

Usual Pediatric Dose for Amebiasis

3 years or older:
Intestinal: 50 mg/kg (up to 2 g) orally once a day with food for 3 days
Amebic liver abscess: 50 mg/kg (up to 2 g) orally once a day with food for 3 to 5 days
Close monitoring is recommended when treatment durations exceed 3 days.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No data available for dosing adjustments for tinidazole. However, caution should be used in dosing patients with severe hepatic dysfunction due to reduction of metabolic elimination of metronidazole in this patient population.

Dose Adjustments

No adjustment recommended

Precautions

Convulsive seizures and peripheral neuropathy have been reported. The drug should be discontinued if patient experiences abnormal neurological symptoms. Tinidazole should be administered cautiously to patients with diseases of the central nervous system.

Tinidazole may produce transient leukopenia and neutropenia, However no persistent hematological abnormalities attributable to tinidazole have been observed clinically. If retreatment is necessary, total and differential leukocyte counts are recommended.

Alcoholic beverages should be avoided during and for 3 days after tinidazole therapy.

Animal studies have revealed carcinogenicity with another agent in the nitroimidazole class (metronidazole). Therefore, unnecessary use of tinidazole should be avoided.

Tinidazole is contraindicated during the first trimester of pregnancy.

Tinidazole is contraindicated in women who are breastfeeding. Interruption of breastfeeding is recommended for the duration of treatment and for 72 hours following the last dose.

To reduce the risk of development of drug resistant organisms, antibiotics should only be used to treat or prevent proven or suspected infections caused by bacteria. Culture and susceptibility information should be considered when selecting treatment or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy. Patients should be advised to avoid missing doses and to complete the entire course of therapy.

Dialysis

Hemodialysis: On the day of hemodialysis, if tinidazole is administered prior to hemodialysis, an additional dose equivalent to one-half of the original dose should be administered after the end of hemodialysis.
Peritoneal dialysis: Data not available

Other Comments

Bioavailability is not affected by food.

For patients unable to swallow tablets, tinidazole tablets may be crushed in artificial cherry syrup and administered with food. The oral suspension may be prepared as follows:
1. Crush four 500 mg oral tablets to a powder with mortar and pestle.
2. Add about 10 mL cherry syrup to the powder and mix until smooth.
3. Transfer the suspension to a graduated amber container.
4. Use several small rinses of cherry syrup to transfer any remaining drug in the mortar to the final suspension for a total volume of 30 mL.

The oral suspension should be shaken well before each administration. The oral suspension of crushed tablets in artificial cherry syrup is stable for 7 days at room temperature.

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