Spironolactone Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Edema

25 to 200 mg/day orally in 1 or 2 divided doses.

Usual Adult Dose for Hypertension

25 to 200 mg/day orally in 1 or 2 divided doses.

Usual Adult Dose for Hypokalemia

25 to 200 mg/day orally in 1 or 2 divided doses.

Usual Adult Dose for Primary Hyperaldosteronism Diagnosis

100 to 400 mg/day orally in 1 or 2 divided doses.

Usual Adult Dose for Hirsutism

50 to 200 mg/day orally in 1 or 2 divided doses.

Usual Adult Dose for Congestive Heart Failure

25 mg/day orally. Increase or decrease based on response and evidence of hyperkalemia.

Usual Adult Dose for Primary Hyperaldosteronism

Initial dose: 100 mg orally once a day. This dosage may be divided into two daily doses, and increased as tolerated every two to three days to a maximum recommended total daily dose of 400 mg. It is recommended that the dosage be titrated to decrease sodium retention, hypertension, weakness, hypokalemia, and any other signs or symptoms of primary hyperaldosteronism in this patient.

If this patient has an adrenal adenoma or carcinoma, the lowest possible spironolactone dosage should be given while waiting for surgery. Adrenal hyperplasia, however, usually does not respond to surgery, and chronic spironolactone therapy is recommended.

Patients with adrenal hyperplasia often require other antihypertensive therapy to control their associated hypertension.

Usual Pediatric Dose for Hypertension

Neonates: 1 to 3 mg/kg/day orally every 12 to 24 hours.
Children: 1.5 to 3.3 mg/kg/day or 60 mg/m2/day orally in divided doses every 6 to 12 hours not to exceed 100 mg/day.

Usual Pediatric Dose for Primary Hyperaldosteronism Diagnosis

Children: 100 to 400 mg/m2/day orally in 1 to 2 divided doses.

Renal Dose Adjustments

CrCl less than 10 mL/min: Not recommended.

CrCl 10 to 50 mL/min: Administer every 12 to 24 hours.

Liver Dose Adjustments

Data not available

Precautions

Spironolactone is contraindicated in patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, or hyperkalemia.

Electrolyte abnormalities (i.e., hyperkalemia, hyponatremia) and renal insufficiency may occur during spironolactone therapy.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Periodic monitoring of serum electrolytes and renal function (i.e., serum creatinine) is recommended.

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