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Spironolactone Dosage

Medically reviewed by Drugs.com. Last updated on Mar 5, 2024.

Applies to the following strengths: 25 mg; 100 mg; 50 mg; 25 mg/5 mL

Usual Adult Dose for Edema

25 to 200 mg orally per day in single or divided doses

Duration of therapy: When given as the sole diuretic, continue the initial dose for at least 5 days, after which the initial dose may be adjusted to an optimal maintenance dose.

Comments:


Uses:

Usual Adult Dose for Hypertension

Initial dose: 50 to 100 mg orally per day in single or divided doses

Duration of therapy: Treatment should be continued for at least 2 weeks to achieve a maximum response. Subsequently, the dose may be adjusted according to patient response.

Usual Adult Dose for Congestive Heart Failure

Initial dose: 25 mg orally once a day assuming serum potassium is less than or equal to 5 mEq/L and serum creatinine is less than or equal to 2.5 mg/dL

Maintenance dose:


Use: To increase survival and reduce the need for hospitalization of severe heart failure patients (New York Heart Association [NYHA] class III to IV) when used in addition to standard therapy.

Usual Adult Dose for Primary Hyperaldosteronism

Diagnostic dose:


Maintenance dose: 100 to 400 mg orally per day until surgery; may be used long-term at the lowest effective dose in patients deemed unsuitable for surgery.

Comments:

Uses:

Usual Adult Dose for Hypokalemia

25 to 100 mg orally per day

Uses:

Renal Dose Adjustments

Contraindicated in patients with anuria, acute renal insufficiency, or significant impairment of renal excretory function.

Liver Dose Adjustments

Use with caution

Dose Adjustments

In patients with severe heart failure (New York Heart Association [NYHA] class III to IV), discontinue or interrupt treatment for serum potassium greater than 5 mEq/L or for serum creatinine greater than 4 mg/dL.

Precautions

US BOXED WARNING:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Monitoring:


Patient advice: Advise patients to avoid potassium supplements and foods containing high levels of potassium, including salt substitutes.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.