Spectracef Dosage

Generic name: cefditoren pivoxil
Dosage form: tablet, film coated

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(See INDICATIONS AND USAGE for Indicated Pathogens.)

SPECTRACEF® (cefditoren pivoxil) Dosage and Administration* Adults and Adolescents (12 Years)

Type of Infection

Dosage

Duration (Days)

Community-Acquired Pneumonia

400 mg BID

14

Acute Bacterial Exacerbation of Chronic Bronchitis

400 mg BID

10

Pharyngitis/Tonsillitis

200mg BID

 

Uncomplicated Skin and Skin Structure Infections

   

*Should be taken with meals

Patients with Renal Insufficiency

No dose adjustment is necessary for patients with mild renal impairment (CLcr: 50-80 mL/min/1.73 m2). It is recommended that not more than 200 mg BID be administered to patients with moderate renal impairment (CLcr: 30-49 mL/min/1.73 m2) and 200 mg QD be administered to patients with severe renal impairment (CLcr: <30 mL/min/1.73 m2). The appropriate dose in patients with end-stage renal disease has not been determined.

Patients with Hepatic Disease

No dose adjustments are necessary for patients with mild or moderate hepatic impairment (Child-Pugh Class A or B). The pharmacokinetics of cefditoren have not been studied in patients with severe hepatic impairment (Child-Pugh Class C).

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