Solifenacin Dosage
This dosage information may not include all the information needed to use Solifenacin safely and effectively. See additional information for Solifenacin.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Urinary Incontinence
5 mg orally per day.
Usual Adult Dose for Urinary Frequency
5 mg orally per day.
Renal Dose Adjustments
CrCl less than 30 mL/min: daily dose should not exceed 5 mg
Liver Dose Adjustments
Solifenacin should not be administered in patients with severe liver dysfunction (Child-Pugh C).
The daily dosage should not exceed 5 mg in patients with moderate liver dysfunction.
Precautions
Solifenacin is contraindicated for use in patients with urinary retention, gastric retention, and uncontrolled narrow-angle glaucoma.
Solifenacin is not recommended in patients with severe hepatic impairment (Child-Pugh C). For patients with moderate hepatic impairment (Child-Pugh B), use with caution and do not exceed a dosage of 5 mg per day.
Caution should be exercised when prescribing solifenacin to patients with a known history of QT prolongation or patients who are taking medications known to prolong the QT interval. A cardiac electrophysiologic study evaluating the QT interval at the time of peak plasma concentrations, following 10 and 30 mg solifenacin doses, has reported a QT prolongation effect. The effect appeared greater with the highest solifenacin dosage, although the effect did not appear as large as that of the positive control moxifloxacin at its therapeutic dose.
Solifenacin should be used with caution in patients with decreased renal function. Doses greater than 5 mg per day are not recommended in patients with creatinine clearance of less than 30 mL/min.
Similar to other drugs with anticholinergic activity, caution should be used in patients with decreased gastrointestinal motility and severe bladder outflow obstruction.
Solifenacin should be used with caution in patients being treated for narrow-angle glaucoma.
Heat prostration may occur when anticholinergic drugs, such as solifenacin, are used in hot weather because of their action on the sweat glands.
The safety and effectiveness of solifenacin in pediatric patients have not been determined.
Dialysis
Data not available
Other Comments
Solifenacin should be swallowed whole. It can be administered with or without food.
