Simvastatin / Sitagliptin Dosage

This dosage information may not include all the information needed to use Simvastatin / Sitagliptin safely and effectively. See additional information for Simvastatin / Sitagliptin.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for Diabetes Type 2

Recommended usual starting dose is 40 mg/100 mg orally once a day in the evening. Patients already taking simvastatin (10, 20, or 40 mg) can initiate simvastatin-sitagliptin at a dose of 100 mg sitagliptin and the dose of simvastatin already being taken.

Usual Adult Dose for Hyperlipidemia

Recommended usual starting dose is 40 mg/100 mg orally once a day in the evening. Patients already taking simvastatin (10, 20, or 40 mg) can initiate simvastatin-sitagliptin at a dose of 100 mg sitagliptin and the dose of simvastatin already being taken.

Usual Adult Dose for Homozygous Familial Hypercholesterolemia

Recommended usual starting dose is 40 mg/100 mg orally once a day in the evening. Patients already taking simvastatin (10, 20, or 40 mg) can initiate simvastatin-sitagliptin at a dose of 100 mg sitagliptin and the dose of simvastatin already being taken.

Usual Adult Dose for Heterozygous Familial Hypercholesterolemia

Recommended usual starting dose is 40 mg/100 mg orally once a day in the evening. Patients already taking simvastatin (10, 20, or 40 mg) can initiate simvastatin-sitagliptin at a dose of 100 mg sitagliptin and the dose of simvastatin already being taken.

Usual Adult Dose for Cardiovascular Risk Reduction

Recommended usual starting dose is 40 mg/100 mg orally once a day in the evening. Patients already taking simvastatin (10, 20, or 40 mg) can initiate simvastatin-sitagliptin at a dose of 100 mg sitagliptin and the dose of simvastatin already being taken.

Renal Dose Adjustments

Simvastatin-sitagliptin is not recommended in patients with severe renal impairment or ESRD.

The recommended starting dose of simvastatin-sitagliptin is 40 mg/50 mg once daily for patients with moderate renal impairment (CrCl greater than or equal to 30 to less than 50 mL/min, approximately corresponding to serum creatinine levels of greater than 1.7 to less than or equal to 3.0 mg/dL in men and greater than 1.5 to less than or equal to 2.5 mg/dL in women). For patients with moderate renal impairment who are already taking simvastatin (10, 20, or 40 mg daily) with or without sitagliptin 50 mg daily, simvastatin-sitagliptin may be initiated at the dose of 50 mg sitagliptin and the dose of simvastatin already being taken.

Simvastatin-sitagliptin can be used in patients with mild renal impairment (creatinine clearance 50 mL/min or more, approximately corresponding to serum creatinine levels of 1.7 mg/dL or lower in men and 1.5 mg/dL or lower in women) without a dose adjustment.

Assessment of renal function is recommended prior to initiation of treatment and periodically thereafter. Creatinine clearance can be estimated from serum creatinine using the Cockcroft-Gault formula. There have been postmarketing reports of worsening renal function in patients with renal impairment treated with sitagliptin, some of whom were prescribed inappropriate doses of sitagliptin.

Liver Dose Adjustments

Simvastatin-sitagliptin is contraindicated in patients with active liver disease which may include unexplained persistent elevations in hepatic transaminase levels.

Dose Adjustments

For patients taking verapamil or diltiazem, the dose of simvastatin-sitagliptin should not exceed 10 mg/100 mg per day. For patients taking amiodarone, amlodipine or ranolazine, the dose of simvastatin-sitagliptin should not exceed 20 mg/100 mg per day.

A dose adjustment of the simvastatin-sitagliptin dose may be necessary to reduce the risk of myopathy, including rhabdomyolysis, if voriconazole must be used concomitantly.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

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