Sildenafil Dosage

This dosage information may not include all the information needed to use Sildenafil safely and effectively. See additional information for Sildenafil.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Erectile Dysfunction

Initial (oral): 50 mg orally administered as needed 1 hour prior to anticipated sexual activity. A maximum of one dose per day is recommended.
Maintenance (oral): 25 to 100 mg orally as needed 30 minutes to 4 hours prior to anticipated sexual activity. A maximum of one dose per day is recommended.

Usual Adult Dose for Pulmonary Hypertension

20 mg orally three times a day taken at least 4 to 6 hours apart
or
10 mg (corresponding to 12.5 mL) administered as an intravenous bolus injection three times a day. A 10 mg dose of the injection is predicted to provide pharmacological effect of sildenafil and its N-desmethyl metabolite equivalent to that of a 20 mg oral dose. The injection is for the continued treatment of patients with pulmonary arterial hypertension (PAH) who are currently prescribed oral sildenafil and who are temporarily unable to take oral medication.

Usual Geriatric Dose for Erectile Dysfunction

25 mg orally as needed 1 hour prior to anticipated sexual activity.

Renal Dose Adjustments

Erectile dysfunction:
CrCl less than 30 mL/min: 25 mg orally as needed 1 hour prior to anticipated sexual activity.

Pulmonary arterial hypertension:
No dose adjustments are required for renal impaired patients (including severe renal impairment with creatinine clearance less than 30 mL/min).

Liver Dose Adjustments

Erectile dysfunction:
25 mg orally as needed 1 hour prior to anticipated sexual activity.

Pulmonary arterial hypertension:
No dose adjustments are required for hepatic impaired patients (Child Pugh class A and B).

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Erectile dysfunction:
25 to 50 mg orally following hemodialysis 1 hour prior to anticipated sexual activity as needed.

Pulmonary arterial hypertension: Give doses after hemodialysis.

Other Comments

Sildenafil for erectile dysfunction has no effect in the absence of sexual stimulation.

Sildenafil potentiates the hypotensive effect of concurrently administered nitrates, therefore patients receiving nitrate therapy should be advised to use an alternate treatment for erectile dysfunction.

Some patients receiving sildenafil may experience a transient visual disturbance which makes objects appear to have a blue tint or hue. While the efficacy of sildenafil in treating erectile dysfunction is associated with its competitive inhibition of phosphodiesterase type 5 causing the release of nitric oxide in the blood vessels of the corpus cavernosum, higher doses may cause a transient inhibition of phosphodiesterase 6 located in the retina, resulting in altered blue/green color discrimination.

Sildenafil is metabolized in the liver by the cytochrome P450 enzyme system, therefore, drugs which are inhibitors or inducers of this system should be expected to alter levels of sildenafil when given concomitantly.

Caution should be exercised when prescribing sildenafil to patients with underlying cardiovascular disease.

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