Secobarbital Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Insomnia

Initial dose: 100 mg orally at bedtime.

Usual Adult Dose for Sedation

Preoperative sedation: 200 to 300 mg orally 1 to 2 hour prior to surgery.

Usual Pediatric Dose for Sedation

Preoperative sedation: 2 to 6 mg/kg orally, up to a maximum of 100 mg.

Renal Dose Adjustments

No specific dose adjustment guidelines have been suggested; however, caution and a dose reduction are recommended in patients with renal dysfunction.

Liver Dose Adjustments

No specific dose adjustment guidelines have been suggested; however, caution and a dose reduction are recommended in patients with liver dysfunction.

Dose Adjustments

Secobarbital should be used at the lowest effective dose in order to achieve therapeutic efficacy and minimize adverse effects, particularly in elderly patients.

Although no specific dose adjustment guidelines have been suggested, a dose reduction is recommended for elderly and debilitated patients.

Precautions

Use of secobarbital is contraindicated in patients with porphyria, significant liver dysfunction, respiratory disease in which dyspnea or obstruction is present, and in patients with a hypersensitivity to barbiturates.

Secobarbital should be administered with caution in patients with a history of substance abuse, depression, or suicidal ideation. In addition, secobarbital should be used with caution in patients with borderline hypoadrenal function, regardless of origin.

Secobarbital should not be administered to patients with premonitory signs of hepatic coma.

Dialysis

Data not available

Other Comments

For the treatment of insomnia, barbiturates appear to lose their efficacy for sleep induction and maintenance after 14 days; therefore, treatment should be limited to this time period.

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