Salsalate Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Osteoarthritis

Usual dose: 3000 mg orally daily, given in divided doses as follows:
Two doses of two 750 mg tablets
OR
Two doses of three 500 mg tablets
OR
Three doses of two 500 mg tablets.

Usual Adult Dose for Rheumatoid Arthritis

Usual dose: 3000 mg orally daily, given in divided doses as follows:
Two doses of two 750 mg tablets
OR
Two doses of three 500 mg tablets
OR
Three doses of two 500 mg tablets.

Renal Dose Adjustments

The manufacturer does not recommend use of salsalate in patients with advanced renal disease. If therapy must be initiated, close monitoring of renal function is advisable.

Liver Dose Adjustments

No adjustment recommended

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Alleviation of symptoms is gradual, and full benefit may not be evident for 3 to 4 days, when plasma salicylate levels have achieved steady state.

The use of salsalate with other salicylates may result in toxic serum salicylate levels. Care should be taken when salsalate is administered in the presence of chronic renal insufficiency or peptic ulcer disease. Salsalate competes with a number of drugs for protein binding sites, therefore, concomitant administration of salsalate and these agents may result in toxic levels of one or both agents. Plasma salicylic acid concentrations should be periodically monitored during long-term treatment with salsalate. Urinary pH should be regularly monitored; sudden acidification may increase plasma salicylate levels.

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