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Rufinamide Dosage

Applies to the following strength(s): 200 mg ; 400 mg ; 40 mg/mL

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Lennox-Gastaut Syndrome

Initial dose: 400 to 800 mg orally per day administered in 2 equally divided doses in the morning and evening

The dose should be increased by 400 to 800 mg per day every 2 days until a maximum daily dose of 3200 mg/day, administered in 2 equally divided doses is reached. It is not known whether doses lower than 3200 mg are effective.

Use: For adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome in pediatric patients 1 year of age and older and in adults

Usual Pediatric Dose for Lennox-Gastaut Syndrome

1 year of age and older:
Initial dose: 10 mg/kg/day orally administered in 2 equally divided doses in the morning and evening

The dose should be increased by approximately 10 mg/kg every other day to a target dose of 45 mg/kg/day or 3200 mg/day, whichever is less, administered in 2 equally divided doses. It is not known whether doses lower than the target dose are effective.

Use: For adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome in pediatric patients 1 year of age and older

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Mild (Child-Pugh 5 to 6) to moderate (Child-Pugh 7 to 9): Caution recommended
Severe hepatic impairment (Child-Pugh 10 to 15): Not recommended

Dose Adjustments

This drug should be withdrawn gradually to reduce the possibility of seizures. In studies discontinuation was achieved by reducing the dose by approximately 25% every 2 days.

Precautions

Safety and efficacy have not been established in patients younger than 1 year.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis reduces plasma levels of this drug by about 30%. Dose adjustments should be considered in patients undergoing dialysis.

Other Comments

Administration advice:
-This drug can be administered whole, cut in half, or crushed and dissolved in a half glass of water.
-This drug should be taken with water.
-Shake the oral suspension well before every administration.
-This drug should be administered with food.

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