Rufinamide Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Lennox-Gastaut Syndrome

Initial dose: 400 to 800 mg/day administered in two equally divided doses.

The dose should be increased by 400 to 800 mg/day every 2 days until a maximum daily dose of 3200 mg/day, administered in two equally divided doses is reached. It is not known whether doses lower than 3200 mg are effective.

Usual Pediatric Dose for Lennox-Gastaut Syndrome

4 years or older:
Initial dose: daily dose of approximately 10 mg/kg/day administered in two equally divided doses.

The dose should be increased by approximately 10 mg/kg increments every other day to a target dose of 45 mg/kg/day or 3200 mg/day, whichever is less, administered in two equally divided doses. It is not known whether doses lower than the target doses are effective.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Use of rufinamide in patients with hepatic impairment has not been studied. Use in patients with severe hepatic impairment is not recommended. Caution is recommended in treating patients with mild to moderate hepatic impairment.

Precautions

Safety and effectiveness have not been established in pediatric patients less than 4 years of age.

Dialysis

No specific dose adjustment guidelines have been suggested. However, it should be noted that hemodialysis reduces plasma levels by about 30%.

Other Comments

Rufinamide tablets marketed as Banzel (R) are scored on both sides and can be cut in half for dosing flexibility. Banzel (R)tablets can be administered whole, as half tablets, or crushed.

Rufinamide should be administered with food.

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