Respiratory Syncytial Virus Immune Globulin Dosage

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Usual Pediatric Dose for:

Additional dosage information:

Usual Pediatric Dose for Respiratory Syncytial Virus

< 24 months: 750 mg/kg/month during the RSV season. The typical RSV season is November through April but regional differences may exist.

The infusion should be gradually increased as tolerated by starting with 1.5 mL/kg/hr for 15 minutes followed by 3.6 mL/kg/hr for remainder of infusion. Rate of infusion should not exceed 3.6 mL/kg/hr. It may be necessary to infuse at a slower rate in some patients, especially ill children with BPD.

Renal Dose Adjustments

There are no data on exact dose adjustments in patients with renal dysfunction. However, renal dysfunction including acute renal failure and osmotic nephrosis, some resulting in death, have been reported in association with immune globulin intravenous (human) products. The incidence may be related to the rate of infusion, product concentration, the presence of sucrose as a stabilizer, or patient characteristics predisposing to acute renal failure.

Liver Dose Adjustments

Data not available

Precautions

Use caution to avoid fluid accumulation when administering RSV-IGIV to patients with underlying pulmonary disease.

Watch for signs of hypersensitivity when administering RSV-IGIV.

Live virus vaccines, including MMR and varicella, should be deferred for 9 months after administration of RSV-IGIV.

Dialysis

Data not available

Other Comments

Vital signs and cardiopulmonary status should be assessed prior to infusion, before each rate increase, and at 30-minute intervals until 30 minutes after infusion.

RSV-IGIV contains sucrose.

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