Generic name: sevelamer carbonate
Dosage form: tablet, film coated
This dosage information does not include all the information needed to use Renvela safely and effectively. See full prescribing information for Renvela.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Because of the rapid reaction with the hydrochloric acid in the stomach, the dosing of Renvela powder or tablet is anticipated to be similar to that of the sevelamer hydrochloride salt or tablet.
General Dosing Information
Renvela should be given three times a day with meals.
Patients Not Taking a Phosphate Binder. The recommended starting dose of Renvela is 0.8 to 1.6 g with meals based on serum phosphorus level. Table 1 provides recommended starting doses of Renvela for patients not taking a phosphate binder.
|Serum Phosphorus||Renvela® 800 mg Tablet||Renvela Powder|
|> 5.5 and < 7.5 mg/dL||1 tablet three times daily with meals||0.8 g three times daily with meals|
|≥ 7.5 mg/dL||2 tablets three times daily with meals||1.6 g three times daily with meals|
Switching from Sevelamer Hydrochloride Tablets. For patients switching from sevelamer hydrochloride tablets to sevelamer carbonate tablets or powder, use the same dose in grams. Further titration may be necessary to achieve desired phosphorus levels. The highest daily dose of sevelamer carbonate studied was 14 grams in CKD patients on dialysis.
Switching between Sevelamer Carbonate Tablets and Powder. Use the same dose in grams. Further titration may be necessary to achieve desired phosphorus levels.
Switching from Calcium Acetate. In a study in 84 CKD patients on hemodialysis, a similar reduction in serum phosphorus was seen with equivalent doses (approximately mg for mg) of sevelamer hydrochloride and calcium acetate. Table 2 gives recommended starting doses of Renvela based on a patient’s current calcium acetate dose.
| Calcium Acetate 667 mg
(Tablets per meal)
|Renvela® 800 mg Tablet
(Tablets per meal)
|1 tablet||1 tablet||0.8 g|
|2 tablets||2 tablets||1.6 g|
|3 tablets||3 tablets||2.4 g|
Dose Titration for All Patients Taking Renvela. Titrate the Renvela dose by 0.8 g three times per day with meals at two-week intervals as necessary with the goal of controlling serum phosphorus within the target range.
Sevelamer Carbonate Powder Preparation Instructions
The entire contents of each 0.8 or 2.4 g packet should be placed in a cup and mixed thoroughly with the amount of water described in Table 3.
| Renvela Powder
|Minimum amount of water for dose preparation
(either ounces, mL or teaspoon/Tablespoon)
|0.8 g||1||30||6 teaspoons/2 Tablespoons|
|2.4 g||2||60||4 Tablespoons|
Multiple packets may be mixed together with the appropriate amount of water. Patients should be instructed to stir the mixture vigorously (it does not dissolve) and drink the entire preparation within 30 minutes and resuspend the preparation right before drinking.
Based on clinical studies, the average prescribed daily dose of sevelamer carbonate is approximately 7.2 g per day.